Antrodia serialis is a polypore living in coniferous trees. It has a sub-surface light-colored fruiting body. Its spores are small and round. Occasionally, small yellow caps may appear on the fruiting body. The spores attach to the wood of the host trees through the surface damage of the bark.

Antrodia serialis mainly lives on Norway spruce (Picea abies) and may sometimes also occur on Scotch pine (Pinus sylvestris). Prevalence area covers the northern hemisphere forest belt.

Antrodia serialis is most often found on fallen trunks of old spruce trees, but it can also decompose the heartwood of a living upright tree. The decomposition process can take a long time, as the fungus leaves the outer healthy layer of the tree alone and the tree can continue to grow. Antrodia serialis can also dismantle wooden structures in the exterior of buildings.

Antrodia serialis is a brown decayer which chooses mainly white cellulose from wood for its nutrition. The species is a common species of old spruce forests. In forestry, preserving deadwood and leaving retention trees and stumps in forests are effective methods to create suitable habitats for Antrodia serialis.